The De Lisio lab at the University of Ottawa is recruiting Doctoral and Postdoctoral candidates interested in cellular and molecular exercise physiology. Work in the De Lisio lab is focused on answering two main questions: (1) What are the external cues that regulate the cellular composition of the stem cell niche, and (2) How do changes in the cellular composition of the stem cell niche regulate stem cell function? To answer these questions, we take an interdisciplinary approach combining in vitro and animal models with human studies, and apply techniques ranging from molecular biology to systems physiology. We focus on stem cell-niche interactions in skeletal muscle and bone marrow in the context of exercise, obesity, and cancer. Our goal is to optimize endogenous stem cell function to maintain tissue health across the lifespan. Current projects include:
The lab is located within the Faculty of Health Sciences’ newly renovated, state-of-the-art “Integrative Health Biology Lab” at Roger Guindon Hall. Our lab’s affiliations with the University of Ottawa Brain and Mind Institute, Regenerative Medicine Program, and Centre on Neuromuscular Disease provide excellent opportunities for collaboration and career development.
The successful candidate will be expected to lead an independent research project, supervise a team of graduate and undergraduate researchers, and disseminate their findings to the broader research community. Experience with cell/molecular biology techniques, animal models, and/or human interventions is desired.
Interested applicants should contact Dr. De Lisio directly (see Contact Tab) with a CV, list of references, unofficial transcript, and one-page statement of research interests.
Grace Niemiro successfully defended her PhD in Spring 2018 at the University of Illinois at Urbana-Champaign. Grace received a graduate student award at the Kinesiology and Community Health Awards Ceremony for her work. She was co-supervised by Dr. Naiman Khan. Grace is currently considering several postdoc offers.
Russel Emmons, De Lisio Lab's first ever graduate student, successfully defended his PhD in Fall 2017 at University of Illinois at Urbana-Champaign. Russ recently accepted a Postdoctoral Research Position at Northwestern University in Chicago.
Canadian Foundation for Innovation
“NeuroHealth and Rehabilitation Research Centre (NHR2C)”.
Collaboration with Dr. Lara Pilutti and Dr. Jason Steffener Labs at uOttawa
Ontario Early Researcher Award
“Investigating the role of mesenchymal stem cells in exercise-induced bone marrow remodeling”.
American Institute of Cancer Research Investigator-Initiated Grant
“The effects of obesity and exercise on radiation-induced leukemia”.
NSERC Discovery Grant
Mechanisms responsible for exercise-induced bone marrow remodeling”.
National Multiple Sclerosis Society
“Lifestyle physical activity intervention for improving cardiorespiratory fitness and vascular comorbidity risk in multiple sclerosis”.
Collaboration with Dr. Lara Pilutti Lab at uOttawa
National Cattlemen’s Beef Association
“The influence of regular beef consumption and protein density of the diet on training induced gains in muscle strength and performance in healthy adults”.
Collaboration with Dr. Nicholas Burd Lab at University of Illinois
Mechanical stimulation promotes hippocampal neurogenesis by muscle-derived MSCs
Interconnection between satellite cells and protein synthesis in muscle adaptation
Obesity impairs protein metabolism in otherwise healthy adults
Kinetics of progenitor cell mobilization in response to exercise
The role of obesity and exercise in hematopoiesis
Dr. De Lisio recently received affiliations with the University of Ottawa Brain and Mind Research Institute, the Centre on Neuromuscular Disease, and the Regenerative Medicine Program.